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Retatrutide is a tri-agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, while semaglutide is a GLP-1 receptor agonist

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Pieber TR, Bode B, Mertens A, Cho YM, Christiansen E, Hertz CL, Wallenstein SOR, Buse JB, PIONEER 7 investigators

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