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Microarray and RNA-sequencing studies have mapped its regulatory effect across approximately 4,000 human genes, including upregulation of VEGF, BDNF, and BMP-2 growth factors central to vascular, neural, and bone remodeling respectively

These studies looked at GLP1-RAs in those with obesity and other comorbidities, without T2D, at weight loss doses

Both upregulate VEGF and angiogenic pathways

Too high levels caused by either excess ROS production or impaired detoxification lead to oxidative stress, elevated tissue damage, and pathophysiological stalling 14,15 , whilst too low levels impede cellular and molecular processes of wound healing which are dependent on ROS-mediated signal transduction 7 ultimately leading to the formation of chronic wounds

11 , e10668 (2019)

Toxic effects of cadmium on testis of birds and mammals: a review