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doi: 10.3389/fpls.2018.01836 Received 28 September 2018 Accepted 27 November 2018 Published 21 December 2018 Volume 9 - 2018 Edited by Stanislav Kopriva, Universitt zu Kln, Germany Reviewed by Aziz Aziz, Universit de Reims Champagne-Ardenne, France

Denosumab (anti-receptor activator of nuclear factor-B ligand antibody) is a RANKL monoclonal antibody that directly inhibits osteoclast-medicated bone resorption by binding to osteoblast-produced RANKL

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