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By targeting both pathways, tirzepatide provides stronger appetite suppression and better metabolic response than single-pathway medications

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Low zinc levels heighten endothelial cell vulnerability to LPS-induced apoptosis, whereas higher intracellular zinc supports defenses against apoptosis, possibly via nitric oxide pathways [473]

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Currently available FDA-approved GLP-1 RAs include several monotherapy agents and one combination multi-agonist, the dual GLP-1/GIP agonist tirzepatide (Zheng et al., 2024)