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Others have reported nausea, vomiting, extreme stomach cramps and have had to seek hospital treatment

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Short-term clinical trials have sometimes reported minimal or no significant shifts in gut microbiota despite marked metabolic improvements

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Binding activates Gq/11 protein signalling, generating IP3 and DAG second messengers that raise intracellular calcium, triggering exocytosis of stored GH granules and stimulating GH gene transcription

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