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Certain genetic mutations, particularly those affecting the X chromosome, can be an underlying cause of premature ovarian insufficiency (also known as primary ovarian insufficiency), a condition in which menstrual cycles become irregular or cease and FSH levels are persistently high before the age of 40 years

The honest answer is that no definitive human data exists

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Mass spectral analyses were accomplished on a quadrupole tandem mass spectrometer (TSQ Quantum Access MAX