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The elevated risk with albiglutide and lixisenatide may relate to prolonged gastric emptying effects, while trizepatide's GIP/GLP-1 dual agonism might offer protective mechanisms

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Immunoprecipitation assay HEK 293 T cells were seeded at 1 10 6 cells per well in 10 cm plates the day before

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Activated IGF-IR phosphorylates IRS1/2 at tyrosine residues and then promotes their association with PI3K, leading to increased PI3K activation, PIP3 abundance, and the activation of PDK1 by PIP3 [45]