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In some cases, tiredness may also be related to an underlying medical condition rather than the drug itself

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If your digestion is working overtime to process a meal, your body diverts blood flow and energy to the gut, which can leave you feeling sleepy

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71 While these findings suggest that GLP-1RAs can reach brain tissue by passive diffusion across the BBB, other research has shown that liraglutide could only enter the brain by binding to the central GLP-1 receptor