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The hydroxylated products are markedly more water-soluble than their precursors and are much more readily excreted from the body

20 FaillieJ.-L.BabaiS.CrpinS.BresV.LarocheM.-L.Le LouetH.et al (2014)

Dihexa is a small peptidomimetic that potentiates hepatocyte growth factor (HGF) signaling through the c-Met receptor at picomolar concentrations, demonstrating exceptional in vitro potency for promoting synaptogenesis

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The biological effect thus persists well beyond plasma presence

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