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Pre-NDA meeting Before submitting the NDA, Eli Lilly will hold a Pre-NDA meeting with the FDA to discuss the submission package

However, analyzing a dsbB mutant strain regarding its oxidation state and re-oxidation capacity in presence or absence of GSH or GSSG revealed that GSSG was still able to complement for the loss of DsbB, indicating a DsbB-independent mechanism (Supplementary figure 4)

Nausea, constipation, diarrhea, bloating, and reduced appetite are frequently reported, especially during dose increases

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