Intravenous administration of lipoic acid at doses of 600 mg/day for three weeks (112) and oral lipoic acid at doses as high as 1,800 mg/day for six months (113) and 1,200 mg/day for two years (76) did not result in serious adverse effects when used to treat diabetic peripheral neuropathy
Avoiding the supplement during these phases is better unless a doctor recommends it
Together, these amino acids create one of the bodys most important antioxidants, supporting natural detox pathways, oxidative balance and cellular wellness
doi: 10.1016/j.jcmgh.2023.09.001 210 PaquetteMGauthierDChamberlandAPratADe Lucia RolfeERasmussenJJet al
Complementary Mechanisms When combined, these compounds create a multi-faceted approach to NO enhancement: Increased Substrate Availability - As described above, L-citrulline effectively raises plasma L-arginine levels, providing more raw material for nitric oxide synthase (NOS) enzymes to produce NO
G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications