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We also found that GH application in the presence of TTX and synaptic blockers depolarized 25% of ARH AgRP neurons (3 out 12 recorded cells from 4 mice), changing in +7.7 1.4 mV their resting membrane potential ( t (2) = 5.277, P = 0.0341)

10.1002/cncr.25860 113 XingF.LiuY.WuS

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Both represent the "next generation" of targeted therapy that moves beyond simple receptor agonism