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Each of the statistical testing strategies were based on the following principles: For a specific dose of semaglutide tablets (e.g., SEM 14 mg), demonstration of superiority on A1C was required before testing for superiority based on other outcomes, such as body weight Establishment of superiority for A1C was required at all higher dosages before continuing testing at lower dosages Non-inferiority must be demonstrated for comparisons to active treatments (or placebo in the CVOT) before testing for superiority PIONEER 9 did not report the use of a testing strategy to control for type 1 error and PIONEER 10 did not adjust for multiplicity

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