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Dysfunction of the tricarboxylic acid (TCA) and urea cycles in CFS (33) and increase in lactic acid and blood urea nitrogen could also be the cause of CFS (34), which could become metabolite markers of CFS

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Retatrutide is Eli Lilly and Company investigational next-generation obesity drug, designed to act on three signals in the body connected to appetite, fullness, blood sugar and energy use: GLP-1, GIP and glucagon