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Based on previous studies done in mice, researchers observed that GLP-1 agonists/DPP-4 inhibitors work to reduce inflammation in the gut, so they proposed that the same mechanism may occur in humans (5, 6)

The TXNIP/NLRP3 signaling pathway, which is involved in the pathogenesis of murine ORG, was screened using a proteomics approach

Ophthalmology 132 (4), P75p162

Kamiski M, Mitkiewska-Dolecka M, Krgielska-Narona M, Bogdaski P

Microscopically, transmural hyperemia of the gastrointestinal tract, intestinal mucosa villi reduction, crypt reduction with focal denudation of superficial epithelia, and large bowel dilatation were all inhibited