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doi: 10.1038/s41591-018-0238-9 259 ZhangRSPadegimasAMurphyKMEvansPTPetersCJDomenicoCMet al

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Mast Cell Hyper-Reactivity (MCAS): As a potent antioxidant, glutathione neutralizes the reactive oxygen species that directly trigger mast cell degranulation, helping to stabilize these immune cells and reduce the systemic release of inflammatory mediators

They are contraindicated for individuals with medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2