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Regulatory approval and clinical confidence rest on the evidence generated from the once-weekly approach, which remains the standard recommendation across medical guidelines

Specifically, in the two studies that reported a reduction in gluconeogenesis, total rates of gluconeogenesis were underestimated because the tracers only gave estimates of the fraction of glucose derived from the infused labelled tracer (i.e

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Sterile technique and professional administration are essential to minimize this risk

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