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According to the phase 3 double-blind clinical trial published in the New England Journal of Medicine, adults with obesity lost an average of 19.5% to 20.9% of body weight on higher tirzepatide doses

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Retatrutide dosage should be understood as clinical-trial context, not a do-it-yourself dosing plan

Rothenbacher, D., Primatesta, P., Ferreira, A., Cea-Soriano, L

A small number of people also had mild changes in heart rhythm (arrhythmias)

Maintaining therapy supports not only ongoing weight loss but also stabilizes metabolic health, ensuring that the initial improvements are not lost over time