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People with low B12 levels often report: Excessive daytime sleepiness Fatigue despite adequate sleep duration Various neurological symptoms that may indirectly affect sleep quality Correcting B12 deficiency typically improves these symptoms over several weeks to months, as the body's stores are replenished and metabolic function normalises

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Impaired BBB integrity Postmortem studies of AD patients and animal models have revealed cellular infiltration, including red blood cells [139], macrophages [140], and neutrophils [141], as well as capillary leakage of blood-derived components such as fibrin(ogen), IgG, albumin, thrombin, and hemosiderin [142,143,144,145]

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