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Expression of EPAC1/2 is upregulated by PI3K-AKT signaling in melanocytes and EPAC2 activity is required for the growth of transformed melanocytes To test whether EPAC signaling is activated and plays a role during malignant transformation of melanocytes, we transformed cultured neonatal human melanocytes (NHM) with lentiviruses for oncogenic BRAF (BRAF V600E ) and/or short hairpin RNA (shRNA) for PTEN (phosphatase and tensin homolog)

One of the most common complaints GPs in Australia hear is that their patients feel exhausted, and want to know how to boost their energy

10.1016/j.addr.2018.04.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Schiller H

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