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Pirro V, et al
PHQ-9, Patient Health Questionnaire 9
Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team
Physiologically, FA is constantly generated through cellular metabolism, i.e., histone and DNA demethylation reactions or the one-carbon cycle, but it can also arise from the diet and it is ubiquitously found in the environment 2,3,4,5
For nausea: Avoid strong smells, especially around mealtimes Try plain crackers, mint, or ginger-based foods or drinks Some people find these work best about 30 minutes after taking their medication For vomiting: Focus on staying well hydrated Choose smaller meals more often instead of large portions For diarrhea: Drink plenty of water Temporarily avoid dairy products and very high-fibre foods until symptoms improve For constipation: Increase fiber slowly rather than all at once Make sure to drink enough fluids alongside fiber General tips: Eat slowly and stop when you feel full Keep portion sizes smaller Avoid vigorous activity immediately after eating Gradual dose increases and personalized dietary adjustments can also help, especially when guided by a healthcare provider
Clinical outcomes and side effect profiles mirror FDA-approved versions
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