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Liu F, Horton-Sparks K, Hull V, Li RW, Martinez-Cerdeno V

However, the miR-21 expression by the influence of curcumin is downregulated in hepatocellular cancer cells, which stimulates the expression of metalloproteinase-3 (TIMP3) and suppresses the GF-b1/smad3 signalling, resulting in the proliferating of cancer cells (Li et al., 2020)

The choice depends on the research model, the desired duration of action, and whether the study is focused on sustained exposure or pulsatile signaling

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Unlike many peptides, BPC-157 is stable in gastric juice, allowing oral administration for GI conditions