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As a naturally occurring copper tripeptide, GHK-Cu plays a critical role in tissue repair, signaling skin remodeling, and modulating inflammation

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Thus, vitamin B12 and/or folate deficiencies can result in lower hemoglobin levels, causing anemia

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GHK-Cu stimulates angiogenesis primarily through upregulation of key growth factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF/FGF-2), with research demonstrating that GHK-Cu at nanomolar concentrations increases VEGF expression in dermal fibroblasts and stimulates human umbilical vein endothelial cell (HUVEC) proliferation through enhanced VEGF and FGF-2 expression