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GLP-1R Mechanisms & Advances in Therapy Review (Signal Transduction & Targeted Therapy, 2024) Full Receptor Biology from -Cell cAMP Signalling to Multi-System Pleiotropic Effects A comprehensive review of GLP-1R mechanisms and therapeutic advances published in Signal Transduction and Targeted Therapy (Nature Publishing Group, 2024) documented the full receptor biology of GLP-1R a class B GPCR found on the surface of multiple cell types

In db/db mouse models of advanced diabetes characterized by uncontrolled hyperglycemia and catabolic weight loss, PG-102 achieved superior and sustained glycemic control compared with semaglutide or tirzepatide while preserving body weight, uncoupling glycemic control from catabolic weight loss

Heymann F, Tacke F

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Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus

Gevi, F., et al