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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

doi: 10.1161/ATVBAHA.120.315267 204 NotzQ.HerrmannJ.SchlesingerT.HelmerP.SudoweS.SunQ.et al

The injectable form relies almost entirely on animal models and community-reported protocols with no published human trials

Drugs, environmental factors, or dietary components can cause liver damage through oxidative stress

12, 2009, pp