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In clinical trials, semaglutide and tirzepatide consistently lower C-reactive protein (CRP), yet only 2060% of that improvement can be explained by weight or glucose changes

Every successfully commercialized transdermal patch drug has those three properties: nicotine (162 Da, logP 1.17), fentanyl (336 Da, logP 4.05), estradiol (272 Da, logP 4.01), testosterone (288 Da, logP 3.32)