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8 In muscle insulin resistance, glucose transport into the cell is impaired

Head-to-head trials -- Direct comparisons (e.g., SURPASS-2 comparing tirzepatide to semaglutide) are needed for other drug pairs Real-world tolerability -- Trial populations may not reflect typical patients, who often have comorbidities and concomitant medications Conclusion# The GI side effect profile of GLP-1 drugs is not uniform

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