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6 Challenges for clinical use of IGF-1R-silencing agents 6.1 Toxicity of IGF-1R antagonists Clinical trials of a large number IGF-1/2, IGF-1R, IRS-1, PI3K and mTOR antagonists have been abandoned due to limited anti-cancer activity, or to the toxicity of these agents (41, 53), further supporting the need to continue studies on LL6 and other molecules that are well tolerated in mice and effective at doses that are not toxic to normal cells (54)

The islands included 2 types of cells: neuroendocrine cells, which have a less-differentiated, primitive appearance and rather scant non-distinct cytoplasm, and large epithelioid cells, which have a more complex, differentiated appearance

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

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Increased endurance: By facilitating fat metabolism, it allows athletes to train longer and delay fatigue