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These track inflammation and general health, not FOXO4-DRI activity directly

Watch for physical or chemical warning signs like swelling or unusual heat

doi: 10.1038/nrc3186 121 ShieldsJDFleuryMEYongCTomeiAARandolphGJSwartzMA

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Transdermal estradiol carries a fundamentally different risk profile from the oral conjugated equine estrogen studied in the WHI route of administration is not a minor detail