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Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance

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Both compounds can cause GI upsetsemaglutide commonly causes nausea and altered bowel habits, while berberine causes diarrhea, cramping, and metallic taste

The compounded medication delivery cadence gets positive mentions for reliability

Exclusion criteria included non-English language articles and studies not focusing on cardiovascular, renal or metabolic influences

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