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Iles and Liu 2005

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Self-reported community sources describe injection-site rotation and slower injection speeds reducing severity

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Involvement of toll-like receptor 3 (TLR3) and activation of astrocytes in poly-I:C signaling TLR3 recognizes viral double-stranded (ds)RNA, mimicked by poly-I:C

If the seal was compromised (cap loose, vial not fully closed), oxygen exposure oxidises the copper ion and potency drops to 6070%