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While short-term use under supervision may be tolerated, extended use could pose unknown risks

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10.1016/j.amjcard.2007.05.022

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3,4 Furthermore, GLP-1R agonists have multiple biological effects that can treat obesity, cardiovascular, neurological, metabolic diseases and play a positive role in tumor therapy

Some frameworks suggest that the interaction of these peptides could influence intracellular mediators relevant to receptor activation and downstream transcriptional regulators