MDPI and ACS Style Kalamkar, S
Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-, and IL-1, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype (97)
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Because cancer cells have significantly elevated glutathione (GSH) levels and a highly reducing intracellular environment, GSH serves as an effective trigger for selective activation of nanocarriers