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Surg Endosc 2024

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Two controlled studies concluded DSIPs sleep effect was of little clinical significance [11] and not likely to be of major therapeutic benefit. [12] That combination minutes-long half-life, non-monotonic dose-response, delayed and persistent effects, and failed replication is precisely why the field stopped

According to clinical trial design, study participants followed reduced-calorie diets, increased physical activity, and received nutritional counseling in addition to medication

This is why dose escalation is intentionally gradual in supervised programs