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This fibrosis, in turn, aggravates hypoxia by increasing the distance between capillaries and tubular epithelial cells, leading to reduced oxygen diffusion efficiency

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N.J.Murray, M.P.Williamson, Conformational study of a salivary proline-rich protein repeat sequence, Eur.J.Biochem., 1993

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To prevent the tooth loss and edentulism in a global scale, regenerative periodontal surgical techniques should be applied when it is indicated