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But, how do we know when we dont have enough for optimal health, and therefore supplementation can help

Supplementation at doses around 200 g/day has consistently reduced thyroid autoantibody titers, and several studies have reported parallel improvements in fatigue, mood, and overall quality of life (195197)

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S., Deng R., Li S., Li X., Li K., Kebaituli G., et al

Enhanced transsulfuration activity driven by the glycine N -methyltransferase may contribute to cysteine biosynthesis and promote cancer cell survival in cysteine-limited microenvironment, which has been demonstrated to support tumor growth in vivo (50)