Oral semaglutide represents a paradigm shift in preventive care
The current recommended number of treatment sessions is 4 to 6 (depending on the severity of the condition), with a 1-week interval between each session
GLP-1 agonist medications have gained widespread attention over the last several years for their role in treating diabetes and supporting weight loss
These medications influence satiety, gastric emptying, insulin response, glucagon regulation, and central appetite signaling
Furthermore, the reduction in adipose tissue mass likely reduced obesity-associated systemic inflammation by reducing the release of pro-inflammatory adipokines, which can drive cartilage degeneration [80] and abnormal subchondral bone remodelling [81]
Another important consequence of NMDA receptor blockade is the decrease in recurrent local feedback inhibition (Grunze et al