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Metformin improves endothelial function and reduces systemic inflammation, while semaglutide decreases arterial stiffness and improves lipid profiles

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J Neurosci 24:81418152 Gilman CP, Perry T, Furukawa K, Grieg NH, Egan JM, Mattson MP (2003) Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons

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Moreover, the fact that L-carnitine tartrate led to a decrease in the mRNA levels of ACE2 suggested that it may play a modulatory role through gene-level effects