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Monthly Cost Comparison Brand-name Ozempic (semaglutide for diabetes): $969 per month without insurance Brand-name Wegovy (semaglutide for weight loss): $1,349 per month without insurance Compounded semaglutide through TrimRx: $199 per month Monthly savings with compounded semaglutide: Versus Ozempic: $770 savings (79% less expensive) Versus Wegovy: $1,150 savings (85% less expensive) 6-Month Treatment Comparison For people using semaglutide for 6 months: Brand-name Ozempic: $5,814 Brand-name Wegovy: $8,094 Compounded semaglutide: $1,194 Savings over 6 months: Versus Ozempic: $4,620 Versus Wegovy: $6,900 12-Month Treatment Comparison For a full year of treatment: Brand-name Ozempic: $11,628 Brand-name Wegovy: $16,188 Compounded semaglutide: $2,388 Savings over 12 months: Versus Ozempic: $9,240 Versus Wegovy: $13,800 18-Month Treatment Comparison Most people need at least 18 months to achieve significant weight loss and stabilization: Brand-name Ozempic: $17,442 Brand-name Wegovy: $24,282 Compounded semaglutide: $3,582 Savings over 18 months: Versus Ozempic: $13,860 Versus Wegovy: $20,700 Cost Per Pound Lost Analysis Clinical trials showed average total body weight loss of 14.9% with semaglutide

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This plays a significant role in appetite regulation and gut hormone signalling

48 , 49 This overview provides the experimental context necessary to interpret the mechanistic and translational findings discussed in subsequent sections