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This insight has profound implications: in obese individuals, simply supplementing NAD+ precursors may fail to restore NAD+ if NNMT continues depleting the coenzyme

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Importantly, these effects occur without changes in food intake, indicating metabolic rather than anorectic mechanisms

Cell Biol Int 43:582592 Dai CC, Huang W, Yang J, Hussein WM, Wang J, Khalil ZG, Capon RJ, Toth I, Stephenson RJ (2021) Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines