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Metabolic B12 deficiency is prevalent, impacting 10%-40% of the population

PMID 8431482

Allergic reactions are uncommon, but if you were to experience symptoms like swelling of the tongue or throat, hives, or difficulty breathing after an injection, that could indicate an allergy and you should seek medical help immediately

I tested heterozygous for A1298C, and changed over to a methyl-folate 440mcg, and a methyl B12

Mu opioid receptor phosphorylation, desensitization, and ligand efficacy

In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )