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And they connect the receptor to the cell internalization machinery, specifically clathrin-coated pits that pull the receptor off the cell surface and into intracellular compartments called endosomes

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This is called post-inflammatory hyperpigmentation (PIH)

Although, there are available data on the development of CMD and the mechanisms associated with its attendant complications, novel mechanisms are still revealed by recent studies in an attempt to open new therapeutic opportunities [4, 5]