how do you wean off glp 1 Stopping GLP-1s: Weight Regain and Maintenance Tips Coming off GLP 1s |

doi: 10.1055/s-2004-826175 141 MeierJJGallwitzBSalmenSGoetzeOHolstJJSchmidtWEet al

cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

These effects are the leading reason patients stop therapy in real-world settings and are a predictable part of initiation

JAMA 327 , 534545 (2022)

Shen WC

Its really important, Stanford says