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evaluated the impact of low-molecular-weight collagen peptides on human skin in a randomized, double-blind, placebo-controlled study of 87 healthy adults (3560 years of age) who had dry skin and periorbital wrinkles on enrollment

The practical distinction in experimental design is compartmental

doi: 10.3390/ijms21010300 192 RizkAYBedaiwyMAAl-InanyHG

Therapeutic modulation of the microbiome shows promise: antibiotics targeting dysbiotic bacteria and fecal microbiota transfer (FMT) reduce lesion growth in preclinical models, while probiotics restoring Lactobacillus dominance improve NK cell activity and reproductive outcomes

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