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A peptide that survives one accidental overnight exposure at 70% of its original potency becomes 49% effective after a second identical exposure (0.70 0.70 = 0.49)

In contrast, when placed under metabolic stress with increased demand on the -cell (induced by high fat feeding and a low dose of the -cell toxin, streptozotocin), glucose tolerance did become impaired, supporting the view that paracrine GLP-1 may be required to maintain glucose homeostasis during adaptation to metabolic stress (114)