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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

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Early and smaller studies suggested effects on fat metabolism and body fat distribution, but larger obesity trials did not show a robust, clinically meaningful weight loss outcome on their own

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Beyond metabolic regulation, 5-Amino-1 MQ is being studied for its possible effects on aging, muscle atrophy, and cellular longevity