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Retatrutide is a triple agonist of GIP, GLP-1, and glucagon receptors, not a third-generation GLP-1

Going On and Off GLP-1s Can Reduce Potential Heart Health Benefits Participants who stopped and restarted a GLP didnt end up getting back to the level of heart protection achieved by people who took the medication consistently

10.1159/000026149 114 OMS (2021)

doi: 10.4158/CS-2019-0472 [DOI] [PubMed] [Google Scholar] 81.Baggio LL, Drucker DJ

The practical impact is concerning: Some women have reported unexpected pregnancies while on the pill and GLP-1s together

While Ozempic mimics one hunger-relieving hormone, and Mounjaro mimics two, Eli Lilly is working on what's called a "triple agonist," with three different hormone-like substances inside