Struck E, Ashmore J, Wieland O
Pineal gland regulation: The tetrapeptide modulates melatonin synthesis in the pineal gland, potentially restoring age-related declines in melatonin production that contribute to disrupted circadian rhythms and reduced antioxidant defense
Neuroprotection Emerging Evidence Evidence Rating: Emerging (Interesting animal data, limited scope) Neurological applications show promise but require more research: Dopaminergic system protection Peripheral nerve regeneration Traumatic brain injury Alcohol-related neurological damage The GABAergic system interactions and NO modulation provide mechanistic support, but this area needs more study
A TUE should be sought for doses in excess of these limits
Epitalon normalized the cortisol rhythm in aged monkeys alongside melatonin restoration (Khavinson et al., 2005)
There needs to be more study done for this substance as far as what kinds of therapeutic uses require what levels of this amino acid to be present