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Convert carefully when comparing protocols from different sources

The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study

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The arguments include the same dose range and same equipotent routes of application, regardless of the injury tested (Sikiric et al., 1993