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They are often prescribed to patients with type 2 diabetes who respond poorly to drugs such as metformin and sulfonylureas

The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

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As Allure previously reported the acne drug is a vitamin A derivative what dermatologists call an "internal retinoid." It works by addressing all four major acne-causing factors by reducing oil production, boosting skin cell turnover, zapping naturally occurring P